Comparison of sequence-dependent tiling array normalization approaches
نویسندگان
چکیده
منابع مشابه
Comments on sequence normalization of tiling array expression
MOTIVATION Methods to improve tiling array expression signals are needed to accurately detect genome features. Royce et al. provide statistical normalizations of tile signal based on probe sequence content that promises improved accuracy, and should be independently verified. RESULTS Assessment of the sequence content normalization methods identified a problem: confounding of probe sequence c...
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MOTIVATION Increases in microarray feature density allow the construction of so-called tiling microarrays. These arrays, or sets of arrays, contain probes targeting regions of sequenced genomes at regular genomic intervals. The unbiased nature of this approach allows for the identification of novel transcribed sequences, the localization of transcription factor binding sites (ChIP-chip), and hi...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2009
ISSN: 1471-2105
DOI: 10.1186/1471-2105-10-204